methanogenesis

In the Shima group, we are interested in the enzymes involved in the biosynthesis of the FeGP cofactor. My project is focused in the catalytic mechanisms of the two radical-SAM enzymes involved in the first and last steps of the biosynthetic pathway.

[Fe]-hydrogenase catalyzes the heterolytic cleavage of H2 and reversible hydride transfer to methenyl-tetrahydromethanopterin. The …